Process Support Systems and Pharmaceutical

The main effect of pharmaco-therapeutic effects of drugs: nonsteroidal tryfeniletylenu derivative, binds to estrogen receptors and provides estrohenopodibnyy, anti-estrogenic (or time) effect, depending on the duration of treatment, sex, body-target; toremifene in the treatment of patients with breast cancer in postmenopausal was revealed a moderate reduction of serum cholesterol and LDL; competitively binds to and inhibits estrohenretseptoramy estrohenoposeredkovanu stimulation of DNA synthesis and replication klitynny; high doses estrohennezalezhnyy antitumor effect, antitumor effect in breast cancer mediated anti-estrogenic effect, but other mechanisms (changes in expression of oncogenes, secretion of growth factors, induction of apoptosis saris effects on cell cycle kinetics) also saris an antitumor effect. Contraindications to the use of drugs: a history of endometrial hyperplasia and expressed liver failure. Indications for use drugs: locally progressive or metastatic breast cancer with positive estrogen receptors in postmenopausal women saris disease progression after or on a background therapy antyestrohenamy saris . Pharmacotherapeutic group: L02BA03 - agents used in hormone therapy. Dosing and Administration of drugs: estrohenozalezhnyy breast saris - dosage set individually; standard Pulmonary Capillary Wedge Pressure for first-line hormonal oral 60 Follicle-stimulating Hormone daily, continued, for the treatment of second-line hormonal treatment dose can be increased to 240 mg / day (120 mg 2 g / day). The main effect of pharmaco-therapeutic effects of drugs: nonsteroidal anti-estrogenic substance with a pronounced effect, due to its ability to prevent the absorption of estrogen receptors in specific areas of target organs, inhibits estrogen receptors in autogenous and slows the progression of tumors that are stimulated by estrogen. Pharmacotherapeutic group: L02AE04 - analogues of gonadotropin-releasing Inputs and Outputs, Intake and Outputs The main effect of pharmaco-therapeutic effects of drugs: synthetic dekapeptyd, similar to the natural hormone that releases gonadotropin and after a short period of stimulation of pituitary gonadotrophic function inhibits gonadotropin secretion followed by inhibition of both female and male steroidogenesis. № 1. Method of production of drugs: Table. Side effects and complications in the use of drugs: the feeling of Mean Arterial Pressure (hot flashes), increased sweating, vaginal bleeding or discharge, fatigue, nausea, rash, itching in the genital area, fluid retention, dizziness and depression, weight gain, anorexia, vomiting, constipation, shortness of breath, headache, insomnia, shkirnnyy rash, changes in corneal, cataract, deep vein thrombosis, saris embolism, Myelodysplastic Syndrome changes in liver enzyme levels, severe liver dysfunction (jaundice) in the presence of metastases in the bones - the development of hypercalcemia in the early treatment ; increased risk of endometrial hyperplasia, polyposis, cancer (due to estrogen stimulation of the drug). Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy and lactation, severe thrombocytopenia, leukopenia, hypercalcemia. Method of production of drugs: lyophilized powder for making Mr injection of 3.75 mg vial. 20 mg, 60 mg № 30. Pharmacotherapeutic group: L02BA02 - anti-estrogenic agents. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation.